منابع مشابه
Mouse model of MYD88L265P-dependent DLBCL.
The frequent detection of a highly recurrent, oncogenic, gain-of-function mutation that substitutes a leucine (L) residue at position 265 of the adapter protein myeloid differentiation primary response gene 88 (MYD88) with a proline (P) residue has implicated the mutant MYD88 allele in the natural history and clinical outcome of an important subset of diffuse DLBCL. However, a genetically engin...
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Diffuse Large B-Cell Lymphomas (DLBCLs) are the most common histologic subtype within non-Hodgkin’s lymphomas (NHLs), accounting for approximately 30% of them. These lymphomas are a heterogeneous clinicopathologic entity characterized by marked phenotypic and clinical differences and several data indeed suggest that under the name of DLBCL different disease entities are currently included. This...
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A preclinical humanized mouse model of thalassemia major or Cooley anemia (CA) was generated by targeted gene replacement of the mouse adult globin genes in embryonic stem cells. The mouse adult and globin genes were replaced with adult human globin genes ( 2 1) and a human fetal to adult hemoglobin (Hb)–switching cassette ( HPFH 0), respectively. Similar to human infants with CA, fully humaniz...
متن کاملA mouse model of ethanol dependent pancreatic fibrosis.
BACKGROUND AND AIMS The majority of patients with chronic pancreatitis are alcoholics. Our goal was to develop a mouse model of alcohol dependent chronic pancreatitis. METHODS Mice were fed either the non-alcohol containing Lieber-DeCarli diet or the Lieber-DeCarli diet containing 24% of calories as ethanol. After eight weeks and while on their respective diets, mice were subjected to repeate...
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A 70-year-old woman presented with 4 weeks of progressive bilateral lower extremity weakness. She had past medical history of stage III diffuse large B-cell lymphoma treated with 6 cycles of R-CHOP chemotherapy, which was completed 6 months prior to presentation. All risk factors for central nervous system (CNS) relapse were negative except for thickening of left paranasal sinus. A computed tom...
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ژورنال
عنوان ژورنال: Blood
سال: 2016
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2016-04-710434